4HVC

Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue

Summary for 4HVC

Entry DOI	10.2210/pdb4hvc/pdb
Descriptor	Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (6 entities in total)
Functional Keywords	ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol : P07814
Total number of polymer chains	2
Total formula weight	120148.09
Authors	Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P. (deposition date: 2012-11-06, release date: 2013-01-02, Last modification date: 2024-02-28)
Primary citation	Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 494:121-124, 2012 Cited by PubMed: 23263184 DOI: 10.1038/nature11774 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation