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5OEH

Molecular tweezers modulate 14-3-3 protein-protein interactions.

Replaces:  4HQW
Summary for 5OEH
Entry DOI10.2210/pdb5oeh/pdb
Descriptor14-3-3 protein sigma, (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, CHLORIDE ION, ... (5 entities in total)
Functional Keywords14-3-3 protein, inhibition, supramolecular ligands, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight27397.11
Authors
Bier, D.,Ottmann, C. (deposition date: 2017-07-07, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citationBier, D.,Rose, R.,Bravo-Rodriguez, K.,Bartel, M.,Ramirez-Anguita, J.M.,Dutt, S.,Wilch, C.,Klarner, F.G.,Sanchez-Garcia, E.,Schrader, T.,Ottmann, C.
Molecular tweezers modulate 14-3-3 protein-protein interactions.
Nat Chem, 5:234-239, 2013
Cited by
PubMed: 23422566
DOI: 10.1038/nchem.1570
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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