4HOP

Crystal structure of the computationally designed NNOS-Syntrophin complex

Summary for 4HOP

Entry DOI	10.2210/pdb4hop/pdb
Related	1QAV
Descriptor	Alpha-1-syntrophin, Nitric oxide synthase, brain (3 entities in total)
Functional Keywords	pdz, protein binding, dimerization, mutation, membrane, membrane protein-oxidoreductase complex, membrane protein/oxidoreductase
Biological source	Mus musculus (mouse) More
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side : Q61234 Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	6
Total formula weight	68037.57
Authors	Harwood, I.M.,Melero, C.,Ollikainen, N.,Kortemme, T. (deposition date: 2012-10-22, release date: 2013-11-06, Last modification date: 2023-09-20)
Primary citation	Melero, C.,Ollikainen, N.,Harwood, I.,Karpiak, J.,Kortemme, T. Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition. Proc.Natl.Acad.Sci.USA, 111:15426-15431, 2014 Cited by PubMed: 25313039 DOI: 10.1073/pnas.1410624111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation