4HN6
GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex
Summary for 4HN6
Entry DOI | 10.2210/pdb4hn6/pdb |
Related | 4HN5 |
Descriptor | Glucocorticoid receptor, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ... (5 entities in total) |
Functional Keywords | glucocorticoid receptor, steroid receptors, dna, ngre, repression, transcription, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150 |
Total number of polymer chains | 4 |
Total formula weight | 35581.58 |
Authors | Hudson, W.H.,Youn, C.E.,Ortlund, E.A. (deposition date: 2012-10-18, release date: 2012-12-12, Last modification date: 2024-02-28) |
Primary citation | Hudson, W.H.,Youn, C.,Ortlund, E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20:53-58, 2013 Cited by PubMed: 23222642DOI: 10.1038/nsmb.2456 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.549 Å) |
Structure validation
Download full validation report