4HLW

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzoimidazole derivatives.

Summary for 4HLW

Entry DOI	10.2210/pdb4hlw/pdb
Descriptor	Androgen receptor, TESTOSTERONE, 2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole, ... (6 entities in total)
Functional Keywords	nuclear hormone receptor, androgen binding domain, transcriptional factor, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10275
Total number of polymer chains	1
Total formula weight	30615.88
Authors	Ravi, S.N.M.,Leblanc, E.,Axerio-Cilies, P.,Labriere, C.,Frewin, K.,Hassona, M.D.H.,Lack, N.A.,Han, F.Q.,Guns, E.S.,Young, R.,Ban, F.,Rennie, P.S.,Cherkasov, A. (deposition date: 2012-10-17, release date: 2013-01-23, Last modification date: 2024-02-28)
Primary citation	Munuganti, R.S.,Leblanc, E.,Axerio-Cilies, P.,Labriere, C.,Frewin, K.,Singh, K.,Hassona, M.D.,Lack, N.A.,Li, H.,Ban, F.,Tomlinson Guns, E.,Young, R.,Rennie, P.S.,Cherkasov, A. Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives. J.Med.Chem., 56:1136-1148, 2013 Cited by PubMed: 23301637 DOI: 10.1021/jm3015712 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation