4HKP

Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide

Summary for 4HKP

• Entry DOI: 10.2210/pdb4hkp/pdb
• Related: 4HIB
• Descriptor: Uridine 5'-monophosphate synthase, GLYCEROL, 5-hydroxycytidine 5'-(dihydrogen phosphate), ... (5 entities in total)
• Functional Keywords: alpha-beta barrel, decarboxylase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 69678.46

Authors

To, T.K.,Kotra, L.P.,Pai, E.F. (deposition date: 2012-10-15, release date: 2012-11-14, Last modification date: 2024-02-28)

• Primary citation: Purohit, M.K.,Poduch, E.,Wei, L.W.,Crandall, I.E.,To, T.,Kain, K.C.,Pai, E.F.,Kotra, L.P.; Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.; J.Med.Chem., 55:9988-9997, 2012; PubMed: 22991951; DOI: 10.1021/jm301176r

Experimental method

X-RAY DIFFRACTION (1.75 Å)