4HJ2
Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil
Summary for 4HJ2
Entry DOI | 10.2210/pdb4hj2/pdb |
Descriptor | Glutathione S-transferase A1, L-gamma-glutamyl-S-(2-{[4-(3-carboxypropyl)phenyl](2-chloroethyl)amino}ethyl)-L-cysteinylglycine (3 entities in total) |
Functional Keywords | alpha-beta, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08263 |
Total number of polymer chains | 2 |
Total formula weight | 51218.88 |
Authors | Karpusas, M.,Chiniadis, L.,Labrou, N.E. (deposition date: 2012-10-12, release date: 2013-03-27, Last modification date: 2024-02-28) |
Primary citation | Karpusas, M.,Axarli, I.,Chiniadis, L.,Papakyriakou, A.,Bethanis, K.,Scopelitou, K.,Clonis, Y.D.,Labrou, N.E. The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis. Plos One, 8:e56337-e56337, 2013 Cited by PubMed: 23460799DOI: 10.1371/journal.pone.0056337 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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