4HIQ

The Structure of V122I Mutant Transthyretin in Complex with AG10

Summary for 4HIQ

• Entry DOI: 10.2210/pdb4hiq/pdb
• Related: 3TCT 4HIS
• Descriptor: Transthyretin, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid (3 entities in total)
• Functional Keywords: thyroid hormone transport, thyroxine, retinol binding protein, hormone binding protein-inhibitor complex, hormone binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28167.38

Authors

Connelly, S.,Alhamadsheh, M.,Graef, I.,Wilson, I.A. (deposition date: 2012-10-11, release date: 2013-06-05, Last modification date: 2023-09-20)

• Primary citation: Penchala, S.C.,Connelly, S.,Wang, Y.,Park, M.S.,Zhao, L.,Baranczak, A.,Rappley, I.,Vogel, H.,Liedtke, M.,Witteles, R.M.,Powers, E.T.,Reixach, N.,Chan, W.K.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.,Alhamadsheh, M.M.; AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.; Proc.Natl.Acad.Sci.USA, 110:9992-9997, 2013; PubMed: 23716704; DOI: 10.1073/pnas.1300761110

Experimental method

X-RAY DIFFRACTION (1.18 Å)