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4HEV

Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate

Summary for 4HEV
Entry DOI10.2210/pdb4hev/pdb
DescriptorBotulinum neurotoxin type A light chain, ZINC ION, N-hydroxy-2-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]acetamide, ... (4 entities in total)
Functional Keywordszn2+-dependent metalloprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceClostridium botulinum
Cellular locationBotulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
Total number of polymer chains2
Total formula weight101753.48
Authors
Silvaggi, N.R.,Allen, K.N. (deposition date: 2012-10-04, release date: 2013-01-23, Last modification date: 2023-09-20)
Primary citationSilhar, P.,Silvaggi, N.R.,Pellett, S.,Johnson, E.A.,Allen, K.N.,Janda, K.D.
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.
Bioorg.Med.Chem., 21:1344-1348, 2013
Cited by
PubMed: 23340139
DOI: 10.1016/j.bmc.2012.12.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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