4HDQ

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and the Heart of Glass (HEG1) cytoplasmic tail

Summary for 4HDQ

Entry DOI	10.2210/pdb4hdq/pdb
Related	4HDO
Descriptor	Krev interaction trapped protein 1, Ras-related protein Rap-1b, Protein HEG homolog 1, ... (7 entities in total)
Functional Keywords	ra binding motif, gtpase, heg1 cytoplasmic tail, ptd domain, rap1 effector, transmembrane protein, rap1, heg1, cell-cell junctions, plasma membrane, nucleus, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton: O00522 Cell membrane: P61224 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential): Q9ULI3
Total number of polymer chains	3
Total formula weight	60201.91
Authors	Gingras, A.R. (deposition date: 2012-10-02, release date: 2013-07-10, Last modification date: 2023-09-20)
Primary citation	Gingras, A.R.,Puzon-McLaughlin, W.,Ginsberg, M.H. The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail. J.Biol.Chem., 288:23639-23649, 2013 Cited by PubMed: 23814056 DOI: 10.1074/jbc.M113.462911 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation