4HCX

Structure of ICDH-1 from M.tuberculosis complexed with NADPH & Mn2+

Summary for 4HCX

Entry DOI	10.2210/pdb4hcx/pdb
Descriptor	Isocitrate dehydrogenase [NADP], MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	icdh-1, rossmann fold, dehydrogenase, nadp binding, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	92802.88
Authors	Hazra, S.,Blanchard, J. (deposition date: 2012-10-01, release date: 2013-02-27, Last modification date: 2024-02-28)
Primary citation	Quartararo, C.E.,Hazra, S.,Hadi, T.,Blanchard, J.S. Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis. Biochemistry, 52:1765-1775, 2013 Cited by PubMed: 23409873 DOI: 10.1021/bi400037w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation