4HCR

Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659

Summary for 4HCR

• Entry DOI: 10.2210/pdb4hcr/pdb
• Related: 4HBQ 4HD9
• Descriptor: PF-547659 heavy chain, PF-547659 light chain, Mucosal addressin cell adhesion molecule 1, ... (4 entities in total)
• Functional Keywords: immunoglobulin superfamily, rolling and firm adhesion, integrin alpha4beta7, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q13477
• Total number of polymer chains: 6
• Total formula weight: 141996.98

Authors

Springer, T.,Yu, Y.,Zhu, J. (deposition date: 2012-10-01, release date: 2013-01-23, Last modification date: 2021-05-26)

• Primary citation: Springer, T.,Yu, Y.,Zhu, J.,Wang, J.-H.,Huang, P.-S.; A Different Fold with an Integrin-Binding Loop Specialized for Flexibility in Mucosal Addressin Cell Adhesion Molecule-1; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.3 Å)