4HAB

Crystal structure of Plk1 Polo-box domain in complex with PL-49

Summary for 4HAB

Entry DOI	10.2210/pdb4hab/pdb
Related PRD ID	PRD_000780
Descriptor	Serine/threonine-protein kinase PLK1, PL-49, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... (5 entities in total)
Functional Keywords	polo-box domain, phosphoprotein-binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P53350
Total number of polymer chains	6
Total formula weight	81221.86
Authors	Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2012-09-26, release date: 2013-04-03, Last modification date: 2022-12-21)
Primary citation	Murugan, R.N.,Park, J.E.,Lim, D.,Ahn, M.,Cheong, C.,Kwon, T.,Nam, K.Y.,Choi, S.H.,Kim, B.Y.,Yoon, D.Y.,Yaffe, M.B.,Yu, D.Y.,Lee, K.S.,Bang, J.K. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21:2623-2634, 2013 Cited by PubMed: 23498919 DOI: 10.1016/j.bmc.2013.02.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation