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4H88

Structure of POM1 FAB fragment complexed with mouse PrPc Fragment 120-230

Summary for 4H88
Entry DOI10.2210/pdb4h88/pdb
Related4DGI
DescriptorMajor prion protein, POM1 FAB CHAIN H, POM1 FAB CHAIN L, ... (5 entities in total)
Functional Keywordsc-term mouse prion protein, pom1 fab, immune system
Biological sourceMus musculus (mouse)
More
Cellular locationCell membrane; Lipid-anchor, GPI-anchor (By similarity): P04925
Total number of polymer chains3
Total formula weight60105.47
Authors
Baral, P.K.,Wieland, B.,Swayampakula, M.,James, M.N. (deposition date: 2012-09-21, release date: 2013-07-31, Last modification date: 2013-09-18)
Primary citationSonati, T.,Reimann, R.R.,Falsig, J.,Baral, P.K.,O'Connor, T.,Hornemann, S.,Yaganoglu, S.,Li, B.,Herrmann, U.S.,Wieland, B.,Swayampakula, M.,Rahman, M.H.,Das, D.,Kav, N.,Riek, R.,Liberski, P.P.,James, M.N.,Aguzzi, A.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Nature, 501:102-106, 2013
Cited by
PubMed: 23903654
DOI: 10.1038/nature12402
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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