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4H85

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-alpha-chloroisocaproate complex with ADP

Summary for 4H85
Entry DOI10.2210/pdb4h85/pdb
Related3TZ4 3TZ5 4DZY 4E00 4H7Q 4H81
Descriptor[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (rat)
Total number of polymer chains1
Total formula weight48015.45
Authors
Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-09-21, release date: 2013-06-05, Last modification date: 2024-02-28)
Primary citationTso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T.
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.
Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013
Cited by
PubMed: 23716694
DOI: 10.1073/pnas.1303220110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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