4H7X
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
Summary for 4H7X
| Entry DOI | 10.2210/pdb4h7x/pdb |
| Related | 4H7Y |
| Descriptor | Dual specificity protein kinase TTK, LEAD (II) ION (3 entities in total) |
| Functional Keywords | mitotic checkpoint kinase, chromosome instability, cancer, tetratricopeptide repeat (tpr) motif, mitotic checkpoint, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 36581.31 |
| Authors | Bolanos-Garcia, V.M.,Chirgadze, D.Y.,Blundell, T.L. (deposition date: 2012-09-21, release date: 2012-12-12, Last modification date: 2024-02-28) |
| Primary citation | Thebault, P.,Chirgadze, D.Y.,Dou, Z.,Blundell, T.L.,Elowe, S.,Bolanos-Garcia, V.M. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem.J., 448:321-328, 2012 Cited by PubMed: 23067341DOI: 10.1042/BJ20121448 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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