4H6S

Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A

Summary for 4H6S

• Entry DOI: 10.2210/pdb4h6s/pdb
• Related: 1SHH 4H6T
• Descriptor: Prothrombin, SODIUM ION, ... (4 entities in total)
• Functional Keywords: serine protease, prethrombin-2, autoactivation, hydrolase, hydrolase-peptide complex, hydrolase/peptide
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 2
• Total formula weight: 33274.20

Authors

Pozzi, N.,Chen, Z.,Zapata, F.,Pelc, L.A.,Di Cera, E. (deposition date: 2012-09-19, release date: 2013-03-13, Last modification date: 2023-09-20)

• Primary citation: Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E.; Autoactivation of thrombin precursors.; J.Biol.Chem., 288:11601-11610, 2013; PubMed: 23467412; DOI: 10.1074/jbc.M113.451542

Experimental method

X-RAY DIFFRACTION (2.19 Å)