4GZ1

Mus Musculus Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex at 1.5 Angstroms resolution

Summary for 4GZ1

• Entry DOI: 10.2210/pdb4gz1/pdb
• Related: 4GYZ 4GZ0 4GZ2
• Descriptor: Tyrosyl-DNA phosphodiesterase 2, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: protein-dna complex, dna repair, 5'-dna end processing, endonuclease/exonuclease/phosphatase domain, eep domain, 5'-dna end recognition, hydrolase-dna complex, hydrolase/dna
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 4
• Total formula weight: 63544.85

Authors

Schellenberg, M.J.,Williams, R.S. (deposition date: 2012-09-05, release date: 2012-10-31, Last modification date: 2024-02-28)

• Primary citation: Schellenberg, M.J.,Appel, C.D.,Adhikari, S.,Robertson, P.D.,Ramsden, D.A.,Williams, R.S.; Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.; Nat.Struct.Mol.Biol., 19:1363-1371, 2012; PubMed: 23104055; DOI: 10.1038/nsmb.2418

Experimental method

X-RAY DIFFRACTION (1.5 Å)