4GVU

Lyngbyastatin 7-Porcine Pancreatic Elastase Co-crystal Structure

Summary for 4GVU

Entry DOI	10.2210/pdb4gvu/pdb
Related PRD ID	PRD_000776
Descriptor	Chymotrypsin-like elastase family member 1, Lyngbyastatin 7, CALCIUM ION, ... (5 entities in total)
Functional Keywords	cyanobacteria, elastase, lyngbyastatin 7, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Sus scrofa (pigs,swine,wild boar) More
Cellular location	Secreted: P00772
Total number of polymer chains	2
Total formula weight	27047.29
Authors	Salvador, L.A.,Taori, K.,Biggs, J.S.,Jakoncic, J.,Ostrov, D.,Paul, V.J.,Luesch, H. (deposition date: 2012-08-31, release date: 2013-02-06, Last modification date: 2023-09-13)
Primary citation	Salvador, L.A.,Taori, K.,Biggs, J.S.,Jakoncic, J.,Ostrov, D.A.,Paul, V.J.,Luesch, H. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J.Med.Chem., 56:1276-1290, 2013 Cited by PubMed: 23350733 DOI: 10.1021/jm3017305 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation