4GV1

PKB alpha in complex with AZD5363

Summary for 4GV1

• Entry DOI: 10.2210/pdb4gv1/pdb
• Descriptor: RAC-alpha serine/threonine-protein kinase, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P31749
• Total number of polymer chains: 1
• Total formula weight: 40191.15

Authors

Addie, M.,Ballard, P.,Bird, G.,Buttar, D.,Currie, G.,Davies, B.,Debreczeni, J.,Dry, H.,Dudley, P.,Greenwood, R.,Hatter, G.,Jestel, A.,Johnson, P.D.,Kettle, J.G.,Lane, C.,Lamont, G.,Leach, A.,Luke, R.W.A.,Ogilvie, D.,Page, K.,Pass, M.,Steinbacher, S.,Steuber, H.,Pearson, S.,Ruston, L. (deposition date: 2012-08-30, release date: 2013-02-27, Last modification date: 2017-11-15)

• Primary citation: Addie, M.,Ballard, P.,Buttar, D.,Crafter, C.,Currie, G.,Davies, B.R.,Debreczeni, J.,Dry, H.,Dudley, P.,Greenwood, R.,Johnson, P.D.,Kettle, J.G.,Lane, C.,Lamont, G.,Leach, A.,Luke, R.W.,Morris, J.,Ogilvie, D.,Page, K.,Pass, M.,Pearson, S.,Ruston, L.; Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases.; J.Med.Chem., 56:2059-2073, 2013; PubMed: 23394218; DOI: 10.1021/jm301762v

Experimental method

X-RAY DIFFRACTION (1.49 Å)