4GS6

Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol

Summary for 4GS6

• Entry DOI: 10.2210/pdb4gs6/pdb
• Related: 2EVA
• Descriptor: Tak1-Tab1 fusion protein, 1,2-ETHANEDIOL, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, ... (4 entities in total)
• Functional Keywords: kinase fold, tab1 binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 36503.97

Authors

Larsen, N.A.,Ferguson, A.D.,Wu, J. (deposition date: 2012-08-27, release date: 2013-01-23, Last modification date: 2017-08-02)

• Primary citation: Wu, J.,Powell, F.,Larsen, N.A.,Lai, Z.,Byth, K.F.,Read, J.,Gu, R.F.,Roth, M.,Toader, D.,Saeh, J.C.,Chen, H.; Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol.; Acs Chem.Biol., 8:643-650, 2013; PubMed: 23272696; DOI: 10.1021/cb3005897

Experimental method

X-RAY DIFFRACTION (2.2 Å)