4GS0

Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide

Summary for 4GS0

Entry DOI	10.2210/pdb4gs0/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 6, Tyrosine-protein kinase JAK1 (3 entities in total)
Functional Keywords	protein-protein complex, phosphatase domain, hydrolase, hydrolase-transferase complex, hydrolase/transferase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P29350 Endomembrane system; Peripheral membrane protein: P23458
Total number of polymer chains	3
Total formula weight	71324.26
Authors	Alicea-Velazquez, N.L.,Jakoncic, J.,Boggon, T.J. (deposition date: 2012-08-27, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Alicea-Velazquez, N.L.,Jakoncic, J.,Boggon, T.J. Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181:243-251, 2013 Cited by PubMed: 23296072 DOI: 10.1016/j.jsb.2012.12.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7961 Å)

Structure validation