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4GQQ

Human pancreatic alpha-amylase with bound ethyl caffeate

Summary for 4GQQ
Entry DOI10.2210/pdb4gqq/pdb
Related1BSI 1CPU 1HNY 3IJ7 3IJ8 4GQR
DescriptorPancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, ... (6 entities in total)
Functional Keywordsglycosyl hydrolase, noncompetitive inhibition, diabetes, obesity, digestion, glycosidase, enzyme inhibition, flavonol, myricetin, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space: P04746
Total number of polymer chains1
Total formula weight56852.68
Authors
Williams, L.K.,Brayer, G.D. (deposition date: 2012-08-23, release date: 2012-10-24, Last modification date: 2020-07-29)
Primary citationWilliams, L.K.,Li, C.,Withers, S.G.,Brayer, G.D.
Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J.Med.Chem., 55:10177-10186, 2012
Cited by
PubMed: 23050660
DOI: 10.1021/jm301273u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation

217705

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