4GQ6

Human menin in complex with MLL peptide

Summary for 4GQ6

• Entry DOI: 10.2210/pdb4gq6/pdb
• Related: 4GPQ 4GQ3 4GQ4
• Descriptor: Menin, Histone-lysine N-methyltransferase MLL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: tumor suppressor, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O00255; Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 2
• Total formula weight: 56739.57

Authors

Shi, A.,Murai, M.J.,He, S.,Lund, G.L.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T. (deposition date: 2012-08-22, release date: 2012-09-19, Last modification date: 2024-02-28)

• Primary citation: Shi, A.,Murai, M.J.,He, S.,Lund, G.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T.; Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.; Blood, 120:4461-4469, 2012; PubMed: 22936661; DOI: 10.1182/blood-2012-05-429274

Experimental method

X-RAY DIFFRACTION (1.55 Å)