4GPT

Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1

Summary for 4GPT

• Entry DOI: 10.2210/pdb4gpt/pdb
• Related: 4GMX
• Descriptor: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
• Functional Keywords: heat repeat, protein nuclear export, kpt251, nuclear, protein transport-inhibitor complex, protein transport/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P62826 P30822; Cytoplasm: P41920
• Total number of polymer chains: 3
• Total formula weight: 163638.64

Authors

Sun, Q.,Chook, Y.M. (deposition date: 2012-08-21, release date: 2012-09-05, Last modification date: 2013-01-23)

• Primary citation: Etchin, J.,Sun, Q.,Kentsis, A.,Farmer, A.,Zhang, Z.C.,Sanda, T.,Mansour, M.R.,Barcelo, C.,McCauley, D.,Kauffman, M.,Shacham, S.,Christie, A.L.,Kung, A.L.,Rodig, S.J.,Chook, Y.M.,Look, A.T.; Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.; Leukemia, 27:66-74, 2013; PubMed: 22847027; DOI: 10.1038/leu.2012.219

Experimental method

X-RAY DIFFRACTION (2.22 Å)