4GK4

Human EphA3 Kinase domain in complex with ligand 90

Summary for 4GK4

Entry DOI	10.2210/pdb4gk4/pdb
Related	4GK2 4GK3
Descriptor	EPH receptor A3, 8-butyl-1-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (3 entities in total)
Functional Keywords	receptor tyrosine kinase, atp-binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40849.61
Authors	Dong, J.,Caflisch, A. (deposition date: 2012-08-10, release date: 2013-01-23, Last modification date: 2023-11-08)
Primary citation	Lafleur, K.,Dong, J.,Huang, D.,Caflisch, A.,Nevado, C. Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography. J.Med.Chem., 56:84-96, 2013 Cited by PubMed: 23253074 DOI: 10.1021/jm301187e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation