4GHA

Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA

Summary for 4GHA

• Entry DOI: 10.2210/pdb4gha/pdb
• Related: 3FKE 3L25 3L26 3LA2 3SK8 4GH9
• Descriptor: Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') (3 entities in total)
• Functional Keywords: viral polymerase, interferon inhibition, dsrna, viral protein, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Marburg virus - Musoke, Kenya, 1980 (MARV); More
• Cellular location: Virion: P35259
• Total number of polymer chains: 6
• Total formula weight: 72835.05

Authors

Bale, S.,Jean-Philippe, J.,Bornholdt, Z.A.,Kimberlin, C.K.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.A.,Kawaoka, Y.,MacRae, I.J.,Wilson, I.A.,Saphire, E.O. (deposition date: 2012-08-07, release date: 2012-08-22, Last modification date: 2023-09-13)

• Primary citation: Bale, S.,Julien, J.P.,Bornholdt, Z.A.,Kimberlin, C.R.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.,Kawaoka, Y.,Macrae, I.J.,Wilson, I.A.,Saphire, E.O.; Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.; Plos Pathog., 8:e1002916-e1002916, 2012; PubMed: 23028316; DOI: 10.1371/journal.ppat.1002916

Experimental method

X-RAY DIFFRACTION (2.5 Å)