4GA7

Crystal structure of human serpinB1 mutant

Summary for 4GA7

• Entry DOI: 10.2210/pdb4ga7/pdb
• Related: 4GAW
• Descriptor: Leukocyte elastase inhibitor (2 entities in total)
• Functional Keywords: serpin, conformational change, serine protease inhibitor, cathepsin g inhibitor, chymase inhibitor, chymotrypsin inhibitor, hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P30740
• Total number of polymer chains: 2
• Total formula weight: 87877.51

Authors

Wang, L.,Li, Q.,Wu, L.,Zhang, K.,Tong, L.,Sun, F.,Fan, Z. (deposition date: 2012-07-25, release date: 2013-01-16, Last modification date: 2023-11-08)

• Primary citation: Wang, L.,Li, Q.,Wu, L.,Liu, S.,Zhang, Y.,Yang, X.,Zhu, P.,Zhang, H.,Zhang, K.,Lou, J.,Liu, P.,Tong, L.,Sun, F.,Fan, Z.; Identification of SERPINB1 as a physiological inhibitor of human granzyme H; J.Immunol., 190:1319-1330, 2013; PubMed: 23269243; DOI: 10.4049/jimmunol.1202542

Experimental method

X-RAY DIFFRACTION (2.9 Å)