4G9J

Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide

Summary for 4G9J

Entry DOI	10.2210/pdb4g9j/pdb
Descriptor	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, synthetic peptide, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	protein phosphatase 1, activating peptide, rvxf binding motif, hydrolase-hydrolase activator complex, hydrolase/hydrolase activator
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P62136
Total number of polymer chains	4
Total formula weight	80950.83
Authors	Sukackaite, R.,Chatterjee, J.,Beullens, M.,Bollen, M.,Koehn, M.,Hart, D.J. (deposition date: 2012-07-24, release date: 2012-09-19, Last modification date: 2023-09-13)
Primary citation	Chatterjee, J.,Beullens, M.,Sukackaite, R.,Qian, J.,Lesage, B.,Hart, D.J.,Bollen, M.,Kohn, M. Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells. Angew.Chem.Int.Ed.Engl., 51:10054-10059, 2012 Cited by PubMed: 22962028 DOI: 10.1002/anie.201204308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation