4G8Z
pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
Summary for 4G8Z
| Entry DOI | 10.2210/pdb4g8z/pdb |
| Related | 1dyr |
| Descriptor | Dihydrofolate reductase, TRIMETHOPRIM, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | mutant pcdhfr inhibitor complex, tmp/nadph ligands, k37s and f69n mutations, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Pneumocystis jirovecii |
| Total number of polymer chains | 1 |
| Total formula weight | 24416.62 |
| Authors | Cody, V. (deposition date: 2012-07-23, release date: 2013-05-29, Last modification date: 2023-09-13) |
| Primary citation | Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A. Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. Antimicrob.Agents Chemother., 57:2669-2677, 2013 Cited by PubMed: 23545530DOI: 10.1128/AAC.00172-13 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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