4G8Y

Crystal structure of Ribonuclease A in complex with 5b

Summary for 4G8Y

Entry DOI	10.2210/pdb4g8y/pdb
Related	4G8V 4G90
Descriptor	Ribonuclease pancreatic, 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine (3 entities in total)
Functional Keywords	nuclease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (bovine,cow,domestic cattle,domestic cow)
Total number of polymer chains	2
Total formula weight	27755.96
Authors	Chatzileontiadou, D.S.M.,Kantsadi, A.L.,Leonidas, D.D. (deposition date: 2012-07-23, release date: 2012-11-21, Last modification date: 2023-09-13)
Primary citation	Parmenopoulou, V.,Chatzileontiadou, D.S.,Manta, S.,Bougiatioti, S.,Maragozidis, P.,Gkaragkouni, D.N.,Kaffesaki, E.,Kantsadi, A.L.,Skamnaki, V.T.,Zographos, S.E.,Zounpoulakis, P.,Balatsos, N.A.,Komiotis, D.,Leonidas, D.D. Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation. Bioorg.Med.Chem., 20:7184-7193, 2012 Cited by PubMed: 23122937 DOI: 10.1016/j.bmc.2012.09.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation