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4G8O

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

Summary for 4G8O
Entry DOI10.2210/pdb4g8o/pdb
Related1B3K 4G8R
DescriptorPlasminogen activator inhibitor 1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsserpin, pai-1, inhibitor, blood clotting, blood clotting-inhibitor complex, blood clotting/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P05121
Total number of polymer chains4
Total formula weight170744.15
Authors
Stuckey, J.A.,Lawrence, D.A.,Li, S.-H. (deposition date: 2012-07-23, release date: 2013-12-25, Last modification date: 2024-02-28)
Primary citationLi, S.H.,Reinke, A.A.,Sanders, K.L.,Emal, C.D.,Whisstock, J.C.,Stuckey, J.A.,Lawrence, D.A.
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.
Proc.Natl.Acad.Sci.USA, 110:E4941-E4949, 2013
Cited by
PubMed: 24297881
DOI: 10.1073/pnas.1216499110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.71 Å)
Structure validation

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