4G8L

Active state of intact sensor domain of human RNase L with 2-5A bound

Summary for 4G8L

• Entry DOI: 10.2210/pdb4g8l/pdb
• Related: 4G8K
• Descriptor: 2-5A-dependent ribonuclease, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE (2 entities in total)
• Functional Keywords: ankyrin-repeat domain, single-stranded rna, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q05823
• Total number of polymer chains: 4
• Total formula weight: 152599.75

Authors

Han, Y.,Whitney, G.,Donovan, J.,Korennykh, A. (deposition date: 2012-07-23, release date: 2012-10-31, Last modification date: 2023-09-13)

• Primary citation: Han, Y.,Whitney, G.,Donovan, J.,Korennykh, A.; Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.; Cell Rep, 2:902-913, 2012; PubMed: 23084743; DOI: 10.1016/j.celrep.2012.09.004

Experimental method

X-RAY DIFFRACTION (2.8 Å)