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4G8A

Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

Summary for 4G8A
Entry DOI10.2210/pdb4g8a/pdb
DescriptorToll-like receptor 4, Lymphocyte antigen 96, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordsleucine rich repeat md-2 related lipid recognition, receptor, innate immunity, lipid binding, glycosylation, immune system
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight184511.91
Authors
Ohto, U.,Shimizu, T. (deposition date: 2012-07-23, release date: 2012-10-17, Last modification date: 2023-11-08)
Primary citationOhto, U.,Yamakawa, N.,Akashi-Takamura, S.,Miyake, K.,Shimizu, T.
Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I
J.Biol.Chem., 287:40611-40617, 2012
Cited by
PubMed: 23055527
DOI: 10.1074/jbc.M112.404608
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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