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4G1Y

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

Summary for 4G1Y
Entry DOI10.2210/pdb4g1y/pdb
DescriptorVitamin D3 receptor A, Nuclear receptor coactivator 1, (4E,6Z)-7-(3-{[3,4-bis(hydroxymethyl)benzyl]oxy}phenyl)-3-ethylnona-4,6-dien-3-ol, ... (4 entities in total)
Functional Keywordsvdr, transcription regulation, nuclear receptor, alpha helical sandwich, ligand, dna, phosphorylation, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceDanio rerio (leopard danio,zebra danio,zebra fish)
More
Cellular locationNucleus: Q9PTN2
Nucleus (By similarity): Q15788
Total number of polymer chains2
Total formula weight36103.16
Authors
Ciesielski, F.,Sato, Y.,Moras, D.,Rochel, N. (deposition date: 2012-07-11, release date: 2012-09-26, Last modification date: 2024-02-28)
Primary citationCiesielski, F.,Sato, Y.,Chebaro, Y.,Moras, D.,Dejaegere, A.,Rochel, N.
Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.
J.Med.Chem., 55:8440-8449, 2012
Cited by
PubMed: 22957834
DOI: 10.1021/jm300858s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

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