4G1Q

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug

Summary for 4G1Q

• Entry DOI: 10.2210/pdb4g1q/pdb
• Related: 1S6Q 1SV5 2IC3 2ZD1 2ZE2 3BGR 3DLK 3V81
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total)
• Functional Keywords: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 115306.17

Authors

Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2012-07-11, release date: 2013-02-06, Last modification date: 2023-09-13)

• Primary citation: Kuroda, D.G.,Bauman, J.D.,Challa, J.R.,Patel, D.,Troxler, T.,Das, K.,Arnold, E.,Hochstrasser, R.M.; Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase.; Nat Chem, 5:174-181, 2013; PubMed: 23422558; DOI: 10.1038/nchem.1559

Experimental method

X-RAY DIFFRACTION (1.51 Å)