4FYO

Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid

Summary for 4FYO

Entry DOI	10.2210/pdb4fyo/pdb
Related	4FYN
Descriptor	Tyrosine-protein kinase SYK, 4-{[(3S)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid (3 entities in total)
Functional Keywords	kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34404.56
Authors	Kuglstatter, A.,Slade, M. (deposition date: 2012-07-05, release date: 2013-01-30, Last modification date: 2023-09-13)
Primary citation	Lucas, M.C.,Goldstein, D.M.,Hermann, J.C.,Kuglstatter, A.,Liu, W.,Luk, K.C.,Padilla, F.,Slade, M.,Villasenor, A.G.,Wanner, J.,Xie, W.,Zhang, X.,Liao, C. Rational design of highly selective spleen tyrosine kinase inhibitors. J.Med.Chem., 55:10414-10423, 2012 Cited by PubMed: 23151054 DOI: 10.1021/jm301367c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation