4FVT

Human SIRT3 bound to Ac-ACS peptide and Carba-NAD

Summary for 4FVT

• Entry DOI: 10.2210/pdb4fvt/pdb
• Related: 4G1C
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Acetylated ACS2 peptide, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: sirtuin, carba-nad, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: Q9NTG7
• Total number of polymer chains: 2
• Total formula weight: 32206.05

Authors

Dai, H. (deposition date: 2012-06-29, release date: 2012-08-15, Last modification date: 2012-09-19)

• Primary citation: Szczepankiewicz, B.G.,Dai, H.,Koppetsch, K.J.,Qian, D.,Jiang, F.,Mao, C.,Perni, R.B.; Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.; J.Org.Chem., 77:7319-7329, 2012; PubMed: 22849721; DOI: 10.1021/jo301067e

Experimental method

X-RAY DIFFRACTION (2.47 Å)