4FR8
Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin
Summary for 4FR8
Entry DOI | 10.2210/pdb4fr8/pdb |
Related | 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 |
Descriptor | Aldehyde dehydrogenase, mitochondrial, propane-1,2,3-triyl trinitrate, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (9 entities in total) |
Functional Keywords | rossmann fold, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion matrix: P05091 |
Total number of polymer chains | 8 |
Total formula weight | 441269.68 |
Authors | Lang, B.S.,Gruber, K. (deposition date: 2012-06-26, release date: 2012-09-26, Last modification date: 2024-02-28) |
Primary citation | Lang, B.S.,Gorren, A.C.,Oberdorfer, G.,Wenzl, M.V.,Furdui, C.M.,Poole, L.B.,Mayer, B.,Gruber, K. Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY. J.Biol.Chem., 287:38124-38134, 2012 Cited by PubMed: 22988236DOI: 10.1074/jbc.M112.371716 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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