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4FR8

Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin

Summary for 4FR8
Entry DOI10.2210/pdb4fr8/pdb
Related1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9
DescriptorAldehyde dehydrogenase, mitochondrial, propane-1,2,3-triyl trinitrate, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (9 entities in total)
Functional Keywordsrossmann fold, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion matrix: P05091
Total number of polymer chains8
Total formula weight441269.68
Authors
Lang, B.S.,Gruber, K. (deposition date: 2012-06-26, release date: 2012-09-26, Last modification date: 2024-02-28)
Primary citationLang, B.S.,Gorren, A.C.,Oberdorfer, G.,Wenzl, M.V.,Furdui, C.M.,Poole, L.B.,Mayer, B.,Gruber, K.
Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY.
J.Biol.Chem., 287:38124-38134, 2012
Cited by
PubMed: 22988236
DOI: 10.1074/jbc.M112.371716
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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