4FL5

Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214

Summary for 4FL5

Entry DOI	10.2210/pdb4fl5/pdb
Related	3LW1 3MHR 3NKX 3P1N
Descriptor	14-3-3 protein sigma, Microtubule-associated protein tau, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	peptide binding protein, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P31947 Cytoplasm, cytosol : P10636
Total number of polymer chains	4
Total formula weight	56069.04
Authors	Schumacher, B.,Ottmann, C. (deposition date: 2012-06-14, release date: 2013-12-11, Last modification date: 2017-06-07)
Primary citation	Joo, Y.,Schumacher, B.,Landrieu, I.,Bartel, M.,Smet-Nocca, C.,Jang, A.,Choi, H.S.,Jeon, N.L.,Chang, K.A.,Kim, H.S.,Ottmann, C.,Suh, Y.H. Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29:4133-4144, 2015 Cited by PubMed: 26103986 DOI: 10.1096/fj.14-265009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation