Summary for 4FK3
| Entry DOI | 10.2210/pdb4fk3/pdb |
| Descriptor | Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (3 entities in total) |
| Functional Keywords | transferase, serine/threonine-protein kinase, atp-binding, oncogenic v600e, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (By similarity): P15056 |
| Total number of polymer chains | 2 |
| Total formula weight | 67092.71 |
| Authors | Zhang, Y.,Wang, W.,Zhang, K.Y.J. (deposition date: 2012-06-12, release date: 2012-08-08, Last modification date: 2024-02-28) |
| Primary citation | Tsai, J.,T Lee, J.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc.Natl.Acad.Sci.USA, 105:3041-3046, 2008 Cited by PubMed: 18287029PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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