4FGH

S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor

Summary for 4FGH

Entry DOI	10.2210/pdb4fgh/pdb
Related	3M08 4FGG
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2E)-3-{5-[(2,4-diamino-6-ethylpyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-yl]prop-2-en-1-one, ... (5 entities in total)
Functional Keywords	oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	20104.66
Authors	Bourne, C.R.,Barrow, W.W. (deposition date: 2012-06-04, release date: 2013-01-09, Last modification date: 2024-02-28)
Primary citation	Nammalwar, B.,Bourne, C.R.,Bunce, R.A.,Wakeham, N.,Bourne, P.C.,Ramnarayan, K.,Mylvaganam, S.,Berlin, K.D.,Barrow, E.W.,Barrow, W.W. Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines. Chemmedchem, 7:1974-1982, 2012 Cited by PubMed: 22930550 DOI: 10.1002/cmdc.201200291 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation