4FDJ

The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc

Summary for 4FDJ

• Entry DOI: 10.2210/pdb4fdj/pdb
• Related: 4FDI
• Descriptor: N-acetylgalactosamine-6-sulfatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: glycoprotein, enzyme replacement therapy, sulfatase, carbohydrate-binding protein, formylglycine, n-linked glycosylation, lysosomal enzyme, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P34059
• Total number of polymer chains: 2
• Total formula weight: 114010.26

Authors

Rivera-Colon, Y.,Garman, S.C. (deposition date: 2012-05-28, release date: 2012-09-05, Last modification date: 2023-12-06)

• Primary citation: Rivera-Colon, Y.,Schutsky, E.K.,Kita, A.Z.,Garman, S.C.; The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A.; J.Mol.Biol., 423:736-751, 2012; PubMed: 22940367; DOI: 10.1016/j.jmb.2012.08.020

Experimental method

X-RAY DIFFRACTION (2.81 Å)