4FAO

Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Summary for 4FAO

Entry DOI	10.2210/pdb4fao/pdb
Descriptor	Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3, Activin receptor type-2B, ... (5 entities in total)
Functional Keywords	tgf-beta, ctk, cystine knot, extracellular domain, receptor, signaling protein-signaling protein complex, signaling protein/signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	36
Total formula weight	459216.20
Authors	Townson, S.A.,Martinez-Hackert, E.,Greppi, C.,Lowden, P.,Sako, D.,Liu, J.,Ucran, J.A.,Liharska, K.,Underwood, K.W.,Seehra, J.,Kumar, R.,Grinberg, A.V. (deposition date: 2012-05-22, release date: 2012-06-20, Last modification date: 2024-04-03)
Primary citation	Townson, S.A.,Martinez-Hackert, E.,Greppi, C.,Lowden, P.,Sako, D.,Liu, J.,Ucran, J.A.,Liharska, K.,Underwood, K.W.,Seehra, J.,Kumar, R.,Grinberg, A.V. Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287:27313-27325, 2012 Cited by PubMed: 22718755 DOI: 10.1074/jbc.M112.377960 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.357 Å)

Structure validation