4F95

Crystal structure of human inosine triphosphate pyrophosphatase P32T variant

Summary for 4F95

• Entry DOI: 10.2210/pdb4f95/pdb
• Related: 2CAR 2I5D 2J4E
• Descriptor: Inosine triphosphate pyrophosphatase (2 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9BY32
• Total number of polymer chains: 1
• Total formula weight: 21754.89

Authors

Simone, P.D.,Pavlov, Y.I.,Borgstahl, G.E.O. (deposition date: 2012-05-18, release date: 2013-04-10, Last modification date: 2023-09-13)

• Primary citation: Simone, P.D.,Struble, L.R.,Kellezi, A.,Brown, C.A.,Grabow, C.E.,Khutsishvili, I.,Marky, L.A.,Pavlov, Y.I.,Borgstahl, G.E.; The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.; J.Struct.Biol., 182:197-208, 2013; PubMed: 23528839; DOI: 10.1016/j.jsb.2013.03.007

Experimental method

X-RAY DIFFRACTION (2.07 Å)