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4F63

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1

Summary for 4F63
Entry DOI10.2210/pdb4f63/pdb
Related4F64 4F65
DescriptorFibroblast growth factor receptor 1, 5-bromo-N~4~-(3-methyl-1H-pyrazol-5-yl)-N~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordskinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains2
Total formula weight71267.43
Authors
Norman, R.A.,Breed, J.,Ogg, D. (deposition date: 2012-05-14, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citationNorman, R.A.,Schott, A.K.,Andrews, D.M.,Breed, J.,Foote, K.M.,Garner, A.P.,Ogg, D.,Orme, J.P.,Pink, J.H.,Roberts, K.,Rudge, D.A.,Thomas, A.P.,Leach, A.G.
Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase.
J.Med.Chem., 55:5003-5012, 2012
Cited by
PubMed: 22612866
DOI: 10.1021/jm3004043
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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