4F2U

Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus

Summary for 4F2U

Entry DOI	10.2210/pdb4f2u/pdb
Related	3V16 3V18 3V1H 4F2B 4F2T
Descriptor	1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	alpha beta barrel, phosphatidylinositol-specific phospholipase c, membrane interface, lyase
Biological source	Staphylococcus aureus subsp. aureus
Cellular location	Secreted: P45723
Total number of polymer chains	1
Total formula weight	35888.91
Authors	Cheng, J.,Goldstein, R.,Stec, B.,Gershenson, A.,Roberts, M.F. (deposition date: 2012-05-08, release date: 2012-12-12, Last modification date: 2023-09-13)
Primary citation	Cheng, J.,Goldstein, R.,Stec, B.,Gershenson, A.,Roberts, M.F. Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity. J.Biol.Chem., 287:40317-40327, 2012 Cited by PubMed: 23038258 DOI: 10.1074/jbc.M112.395277 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation