4EPH

CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX with CoA-site inhibitor

Summary for 4EPH

Entry DOI	10.2210/pdb4eph/pdb
Related	2DEB 2FW3 2FYO 2H4T 2RCU 4EP9
Descriptor	Carnitine O-palmitoyltransferase 2, mitochondrial, 2-chloro-4-[({1-[(5-chloro-2-methoxyphenyl)sulfonyl]-4-methyl-2,3-dihydro-1H-indol-6-yl}carbonyl)amino]benzoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	transferase, acyltransferase, mitochondrial protein, coa, acylcarnitine, mitochondrial inner membrane, lipid transport, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Total number of polymer chains	1
Total formula weight	74393.86
Authors	Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (deposition date: 2012-04-17, release date: 2013-04-17, Last modification date: 2023-09-13)
Primary citation	Perspicace, S.,Rufer, A.C.,Thoma, R.,Mueller, F.,Hennig, M.,Ceccarelli, S.,Schulz-Gasch, T.,Seelig, J. Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein. FEBS Open Bio, 3:204-211, 2013 Cited by PubMed: 23772395 DOI: 10.1016/j.fob.2013.04.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation