4EN2

HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)

Summary for 4EN2

• Entry DOI: 10.2210/pdb4en2/pdb
• Related: 4EMZ
• Descriptor: AP-1 complex subunit mu-1, Protein Nef, MHC-I, ... (4 entities in total)
• Functional Keywords: human immunodeficiency virus 1, hiv, nef, mhc-i, antigen presentation, host defense, adaptor protein complex 1, mu1 adaptin subunit, sorting motif recognition, clasp, membrane trafficking, viral hijacking, viral protein-immune system complex, viral protein/immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Golgi apparatus: P35585; Host cell membrane ; Lipid-anchor ; Cytoplasmic side : Q90VU7
• Total number of polymer chains: 6
• Total formula weight: 113520.66

Authors

Jia, X.,Xiong, Y. (deposition date: 2012-04-12, release date: 2012-06-20, Last modification date: 2024-02-28)

• Primary citation: Jia, X.,Singh, R.,Homann, S.,Yang, H.,Guatelli, J.,Xiong, Y.; Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.; Nat.Struct.Mol.Biol., 19:701-706, 2012; PubMed: 22705789; DOI: 10.1038/nsmb.2328

Experimental method

X-RAY DIFFRACTION (2.58 Å)