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4EEF

Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin.

Summary for 4EEF
Entry DOI10.2210/pdb4eef/pdb
DescriptorHemagglutinin HA1 chain, Hemagglutinin HA2 chain, F-HB80.4, DESIGNED HEMAGGLUTININ BINDING PROTEIN, ... (5 entities in total)
Functional Keywordsimmunoglobulin, hemagglutinin, fusion of virus membrane with host membrane, membrane fusion, sialic acid, virion, immune system, immune system-inhibitor complex, immune system/inhibitor
Biological sourceInfluenza A virus
More
Cellular locationVirion membrane; Single-pass type I membrane protein (Potential): Q9WFX3 Q9WFX3
Total number of polymer chains9
Total formula weight198733.63
Authors
Dreyfus, C.,Wilson, I.A. (deposition date: 2012-03-28, release date: 2012-06-27, Last modification date: 2020-07-29)
Primary citationWhitehead, T.A.,Chevalier, A.,Song, Y.,Dreyfus, C.,Fleishman, S.J.,De Mattos, C.,Myers, C.A.,Kamisetty, H.,Blair, P.,Wilson, I.A.,Baker, D.
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing.
Nat.Biotechnol., 30:543-548, 2012
Cited by
PubMed: 22634563
DOI: 10.1038/nbt.2214
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.704 Å)
Structure validation

217705

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